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KMID : 1036320160380010038
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Maxillofacial Plastic and Reconstructive Surgery
2016 Volume.38 No. 1 p.38 ~ p.38
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Chitin-fibroin-hydroxyapatite membrane for guided bone regeneration: micro-computed tomography evaluation in a rat model
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Baek Young-Jae
Kim Jung-Han
Song Jae-Min
Yoon Sang-Yong
Kim Hong-Sung
Shin Sang-Hun
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Abstract
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Background: In guided bone regeneration (GBR) technique, many materials have been used for improving biological effectiveness by adding on membranes. The new membrane which was constructed with chitin-fibroin-hydroxyapatite (CNF/HAP) was compared with a collagen membrane (Bio-Gide®) by means of micro-computed tomography.
Methods: Fifty-four rats were used in this study. A critical-sized (8 mm) bony defect was created in the calvaria with a trephine bur. The CNF/HAP membrane was prepared by thermally induced phase separation. In the experimental group (n?=?18), the CNF/HAP membrane was used to cover the bony defect, and in the control group (n?=?18), a resorbable collagen membrane (Bio-Gide®) was used. In the negative control group (n?=?18), no membrane was used. In each group, six animals were euthanized at 2, 4, and 8 weeks after surgery. The specimens were analyzed using micro-CT.
Results: Bone volume (BV) and bone mineral density (BMD) of the new bone showed significant difference between the negative control group and membrane groups (P?
Conclusions: The CNF/HAP membrane has significant effect on the new bone formation and has the potential to be applied for guided bone regeneration.
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KEYWORD
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Chitin-fibroin-hydroxyapatite, Guided bone regeneration, Micro-computed tomography, Rat calvarial defect
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